netFormulary Coventry and Warwickshire Area Prescribing Committee NHS
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 Formulary Chapter 8: Malignant disease and immunosuppression - Full Chapter
08.02  Expand sub section  Drugs affecting the immune response
Blinatumomab
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Formulary
Red SO
Treatment of adults with Philadelphia chromosome negative relapsed or refractory B-precursor acute lymphoblastic leukaemia
 
Link  NICE TA450: Blinatumomab for previously treated Philadelphia-chromosome-negative acute lymphoblastic leukaemia – guidance
   
Inotuzumab ozogamicin
(Restricted Item)
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Formulary
Red SO
Treatment of acute lymphoblastic leukaemia
 
   
08.02  Expand sub section  Immunosuppressant therapy
08.02.01  Expand sub section  Antiproliferative immunosuppressants
Cytotoxic Drug Azathioprine
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Formulary
Amber SC
Treatment of autoimmune cytopenias and dermatomyositis 
Link  Azathioprine - shared care agreement
   
Mycophenolate Mofetil
(Renal)
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Formulary
Red SO

Prophylaxis of transplant rejection in renal, liver and heart transplant patients and treatment of vasculitis, glomerulonephritis and lupus

 
   
Cytotoxic Drug Azathioprine
(Renal)
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Formulary
Red SO

Suppression of renal transplant rejection and treatment of vasculitis

 
   
08.02.02  Expand sub section  Corticosteroids and other immunosuppressants
Ciclosporin
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Formulary
Amber SC
Treatment of nephrotic syndrome -
must prescribe by brand 
Link  Ciclosporin - shared care agreement
   
Basiliximab
(adolescents and children )
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Formulary
Red SO
Prophylaxis of acute rejection in allogenic renal transplant
 
   
Ciclosporin
(Renal)
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Formulary
Red SO

Suppression of renal transplant rejection

 
   
Daclizumab
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Formulary
Red SO
Treatment of relapsing forms of multiple sclerosis
 
Link  NICE TA441: Daclizumab for treating relapsing–remitting multiple sclerosis
   
Cytotoxic Drug Everolimus
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Formulary
Red SO
Prophylaxis of organ rejection following heart, renal or liver transplantation
 
Link  NICE TA348: Everolimus for preventing organ rejection in liver transplantation
   
Cytotoxic Drug Sirolimus
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Formulary
Red SO

Suppression of renal transplant rejection

 
   
Tacrolimus
(Renal)
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Formulary
Red SO

Prophylaxis of organ rejection – Renal, liver and heart transplant
Prescribe by brand

 
   
08.02.03  Expand sub section  Anti-lymphocyte monoclonal antibodies to top
Alemtuzumab
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Formulary
Red SO
Treatment of relapsing remitting multiple sclerosis with active disease
 
Link  NICE TA312: Alemtuzumab for treating relapsing‑remitting multiple sclerosis
   
Catumaxomab
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Formulary
Red SO
Treatment of malignant ascites in patients with epithelial cell adhesion molecule positive carcinomas
 
   
Daratumumab
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Formulary
Red SO
Treatment of relapsed and refractory multiple myeloma
 
Link  NICE TA510:Daratumumab monotherapy for treating relapsed and refractory multiple myeloma
   
Obinutuzumab
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Formulary
Red SO
Treatment of leukaemia and lymphoma
 
Link  NICE TA343: Obinutuzumab in combination with chlorambucil for untreated chronic lymphocytic leukaemia
Link  NICE TA513: Obinutuzumab for untreated advanced follicular lymphoma
   
Ofatumumab
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Formulary
Red SO
Treatment of chronic lymphocytic leukaemia
 
Link  NICE TA202: Chronic lymphocytic leukaemia - ofatumumab
Link  NICE TA344: Ofatumumab in combination with chlorambucil or bendamustine for untreated chronic lymphocytic leukaemia
   
Rituximab
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Formulary
Red SO
Treatment of lymphomas and chronic lymphocytic leukaemia, and anti-neutrophil cytoplasmic antibody-associated vasculitis


 
Link  NICE TA137: Lymphoma (follicular non-Hodgkin's) - rituximab
Link  NICE TA174: Leukaemia (chronic lymphocytic, first line) - rituximab
Link  NICE TA193: Leukaemia (chronic lymphocytic, relapsed) - rituximab
Link  NICE TA226: Lymphoma (follicular non-Hodgkin’s) - rituximab
Link  NICE TA243: Rituximab for the first-line treatment of stage III-IV follicular lymphomalymphoma
Link  NICE TA308: Rituximab in combination with glucocorticoids for treating anti-neutrophil cytoplasmic antibody-associated vasculitis
   
08.02.04  Expand sub section  Other immunomodulating drugs
Canakinumab
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Formulary
Red SO
Treatment for all licensed indications 
   
Cobimetinib
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Formulary
Red SO
Treatment of unresectable or metastatic melanoma with a BRAF V600 mutation

 
   
Dimethyl fumarate (Tecfidera®)
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Formulary
Red SO

Treatment of relapsing remitting multiple sclerosis

 
Link  NICE TA320: Dimethyl fumarate for treating relapsing‑remitting multiple sclerosis
   
Fampridine
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Formulary
Red SO
Improvement of walking disability in multiple sclerosis
 
   
Fingolimod
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Formulary
Red SO

Treatment of highly active relapsing-remitting multiple sclerosis

 
Link  NICE TA254: Fingolimod for highly active relapsing remitting multiple sclerosis
   
Histamine
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Formulary
Red SO
Treatment of Acute Myeloid Leukaemia in combination with aldesleukin
 
   
Lenalidomide
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Formulary
Red SO
Treatment of myelodysplastic syndrome, multiple myeloma and mantle cell lymphoma
 
Link  NICE TA171: Multiple myeloma - lenalidomide
Link  NICE TA322: Lenalidomide for treating myelodysplastic syndromes associated with an isolated deletion 5q cytogenetic abnormality
   
Nivolumab
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Formulary
Red SO
Treatment of melanoma, lung and renal cancer
 
Link  NICE TA384: Nivolumab for treating advanced (unresectable or metastatic) melanoma
Link  NICE TA417: Nivolumab for previously treated advanced renal cell carcinoma
Link  NICE TA462: Nivolumab for treating relapsed or refractory classical Hodgkin lymphoma
Link  NICE TA483: Nivolumab for previously treated squamous non-small-cell lung cancer
Link  NICE TA484: Nivolumab for previously treated non-squamous non-small-cell lung cancer
Link  NICE TA490: Nivolumab for treating squamous cell carcinoma of the head and neck after platinum-based chemotherapy
   
Teriflunomide
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Formulary
Red SO
Treatment of relapsing remitting multiple sclerosis
 
Link  NICE TA303: Teriflunomide for relapsing remitting MS
   
08.02.04  Expand sub section  Interferon Alfa
Interferon Alfa
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Formulary
Red SO
 
   
Peginterferon alfa (2a & 2b)
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Formulary
Red SO
Treatment of hepatitis B and C
 
Link  NICE TA106: Hepatitis C - peginterferon alfa & ribavirin
Link  NICE TA200: Hepatitis C - peginterferon alfa & ribavirin
Link  NICE TA300: Hepatitis C (children and young people) - peginterferon alfa and ribavirin
Link  NICE TA75: Hepatitis C - pegylated interferons, ribavirin & alfa interferon
   
08.02.04  Expand sub section  Interferon beta
Interferon Beta
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Formulary
Red SO
Treatment of multiple sclerosis
 
   
08.02.04  Expand sub section  Aldesleukin
Aldesleukin (Proleukin®)
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Formulary
Red SO
Treatment of renal cell carcinoma
 
   
BCG bladder instillation
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Formulary
Red SO
Treatment of carcinoma-in-situ of the urinary bladder and prevention of recurrence of superficial papillary transitional cell carcinoma of the urinary bladder after transurethral resection
 
   
Mifamurtide (®)
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Formulary
Red SO
Treatment of osteosarcoma
 
Link  NICE TA154: Hepatitis B - telbivudine
   
08.02.04  Expand sub section  Glatiramer acetate to top
Glatiramer Acetate
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Formulary
Red SO
Treatment of multiple sclerosis
 
   
08.02.04  Expand sub section  Natalizumab
Natalizumab
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Formulary
Red SO
Treatment of highly active relapsing remitting multiple sclerosis
 
Link  NICE TA127: Multiple sclerosis - natalizumab
   
 ....
 Non Formulary Items
Pomalidomide  (Imnovid®)

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Non Formulary
Not Recommended
Relapsed and refractory multiple myeloma in combination with dexamethasone after at least two prior treatment regimens, including both lenalidomide and bortezomib with demonstrated disease progression on the last therapy
Link  NICE TA338: Pomalidomide for relapsed and refractory multiple myeloma previously treated with lenalidomide and bortezomib
 
  
Key
note Notes
Section Title Section Title (top level)
Section Title Section Title (sub level)
First Choice Item First Choice item
Non Formulary Item Non Formulary section
Restricted Drug
Restricted Drug
Unlicensed Drug
Unlicensed
Track Changes
Display tracking information
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Link to adult BNF
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Link to children's BNF
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Link to SPCs
SMC
Scottish Medicines Consortium
Cytotoxic Drug
Cytotoxic Drug
CD
Controlled Drug
High Cost Medicine
High Cost Medicine
Blueteq
High Cost Drug Approval System

Traffic Light Status Information

Status Description

Preferred

Clinicians are free to prescribe these drugs. They are regarded as cost effective choices which have evidence to support their use.  

Second Line

These drugs should only be prescribed in the scenarios described in the formulary after preferred drug(s) have been ruled out.  

Non Formulary

Non-formulary choice - the vast majority of a patient’s needs should be met by use of formulary preferred choices and second line options when appropriate. Therefore the Clinician should only use a non-formularly drug if this can be justified and it is recommended that all such instances are recorded in the patient record.  

Green SA

Specialist Advised – Specialists may simply advise a patient’s GP to initiate these drugs themselves after they have made an initial assessment. Note: SA drugs can be initiated by the specialist according to patient need and also depending on local commissioning arrangements which may mandate, through the contract between provider and commissioner, that all SA drugs are treated as SI.  

Green SI

Specialist Initiation - These drugs must be initiated, i.e. the first dose prescribed, by the specialist and then may be continued when appropriate by the patient’s GP following communication from the specialist.  

Amber SC

Shared Care - Responsibility for prescribing may be transferred from secondary to primary care with the agreement of an individual GP and when agreed shared care arrangements have been established. The specialist MUST stabilize the patient before asking for care to be transferred. Only specialists should initiate these drugs. Prescribing should be transferred to GPs according to an Shared Care Agreement [SCA]   

Red SO

Specialist Only - These drugs are deemed to be not appropriate for prescribing by GPs. Specialists should not ask GPs to prescribe these drugs.   

Black BL

Black Listed Medicines - These drugs are considered inappropriate for prescribing in Coventry & Warwickshire as they are either not cost-effective or of proven benefit or both.   

Not Recommended

Not Recommended - These are specialist drugs that are not recommended for use.  

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